During collective migration, only a few cells become leaders that guide tissue movement. Here, the authors show that contractile forces drive lysosomes to the cell edge, where they activate Rac1 and trigger leader cell emergence.
Author: Rituraj Marwaha, Diya Manoj, Simran Rawal, Purnati Khuntia, Sanak Banerjee, Praver Gupta, Basil Thurakkal, Manish Jaiswal, Tamal Das
Published at: 2025-12-21 00:00:00
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